Phenotypes Associated with This Genotype

Genotype
MGI:2683072

• Allelic Composition: Perp^tm1Att/Perp^tm1Att
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:86549 )

• the majority of mice die postnatally

cellular

decreased cellular sensitivity to gamma-irradiation ( J:86549 )

• thymocyte cell death after gamma-irradiation is decreased compared to wild-type

• subventricular zone of the E13.5 brain shows less apoptosis after gamma-irradiation than in wild-type embryos

decreased thymocyte apoptosis ( J:86549 )

• thymocyte cell death after gamma-irradiation is decreased compared to wild-type

decreased neuron apoptosis ( J:86549 )

• subventricular zone neurons of the E13.5 mutant brain show less apoptosis after gamma-irradiation than in wild-type embryos

immune system

decreased thymocyte apoptosis ( J:86549 )

• thymocyte cell death after gamma-irradiation is decreased compared to wild-type

nervous system

decreased neuron apoptosis ( J:86549 )

• subventricular zone neurons of the E13.5 mutant brain show less apoptosis after gamma-irradiation than in wild-type embryos

hematopoietic system

decreased thymocyte apoptosis ( J:86549 )

• thymocyte cell death after gamma-irradiation is decreased compared to wild-type

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:86549 )

• thymocyte cell death after gamma-irradiation is decreased compared to wild-type