Phenotypes Associated with This Genotype

Genotype
MGI:2683964

• Allelic Composition: Gata3^tm1Iho/Gata3^tm1Iho; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:86996 )

• fewer than the expected numbers (6.5% vs 12.5%) of mutants are born, indicating partial prenatal lethality; time of lethality not determined

hematopoietic system

increased T cell apoptosis ( J:86996 )

• those double negative (DN) 3 cells that are able to develop into DN4 cells, exhibit increased apoptosis compared to controls

small thymus ( J:86996 )

decreased thymocyte number ( J:86996 )

• decrease in total thymocyte number at 4-6 weeks of age

• 10-fold reduction in the number of alpha/beta TCR+ thymocytes

decreased double-positive T cell number ( J:86996 )

arrested T cell differentiation ( J:86996 )

• double negative (DN) thymocytes fail to develop into large active double positive thymocytes

• accumulation of cells in the CD44-CD25+ DN3 stage and decreased CD44-CD25- DN4 cells, indicating a partial arrest at the DN3 to DN4 transition

abnormal T cell subpopulation ratio ( J:86996 )

• reduction in the CD4/CD8 ratio (1.33 vs 3-4 in controls)

decreased CD4-positive, alpha-beta T cell number ( J:86996 )

abnormal CD8-positive, alpha-beta T cell number ( J:86996 )

• variable numbers of total SP CD8 cell numbers, with a decrease in most cases but increases in other cases

immune system

increased T cell apoptosis ( J:86996 )

• those double negative (DN) 3 cells that are able to develop into DN4 cells, exhibit increased apoptosis compared to controls

small thymus ( J:86996 )

decreased thymocyte number ( J:86996 )

• decrease in total thymocyte number at 4-6 weeks of age

• 10-fold reduction in the number of alpha/beta TCR+ thymocytes

decreased double-positive T cell number ( J:86996 )

arrested T cell differentiation ( J:86996 )

• double negative (DN) thymocytes fail to develop into large active double positive thymocytes

• accumulation of cells in the CD44-CD25+ DN3 stage and decreased CD44-CD25- DN4 cells, indicating a partial arrest at the DN3 to DN4 transition

abnormal T cell subpopulation ratio ( J:86996 )

• reduction in the CD4/CD8 ratio (1.33 vs 3-4 in controls)

decreased CD4-positive, alpha-beta T cell number ( J:86996 )

abnormal CD8-positive, alpha-beta T cell number ( J:86996 )

• variable numbers of total SP CD8 cell numbers, with a decrease in most cases but increases in other cases

cellular

increased T cell apoptosis ( J:86996 )

• those double negative (DN) 3 cells that are able to develop into DN4 cells, exhibit increased apoptosis compared to controls

endocrine/exocrine glands

small thymus ( J:86996 )

decreased thymocyte number ( J:86996 )

• decrease in total thymocyte number at 4-6 weeks of age

• 10-fold reduction in the number of alpha/beta TCR+ thymocytes