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Phenotypes Associated with This Genotype
Genotype
MGI:2683964
Allelic
Composition
Gata3tm1Iho/Gata3tm1Iho
Tg(Lck-cre)1Cwi/0
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Iho mutation (0 available); any Gata3 mutation (32 available)
Tg(Lck-cre)1Cwi mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than the expected numbers (6.5% vs 12.5%) of mutants are born, indicating partial prenatal lethality; time of lethality not determined

hematopoietic system
• those double negative (DN) 3 cells that are able to develop into DN4 cells, exhibit increased apoptosis compared to controls
• decrease in total thymocyte number at 4-6 weeks of age
• 10-fold reduction in the number of alpha/beta TCR+ thymocytes
• double negative (DN) thymocytes fail to develop into large active double positive thymocytes
• accumulation of cells in the CD44-CD25+ DN3 stage and decreased CD44-CD25- DN4 cells, indicating a partial arrest at the DN3 to DN4 transition
• reduction in the CD4/CD8 ratio (1.33 vs 3-4 in controls)
• variable numbers of total SP CD8 cell numbers, with a decrease in most cases but increases in other cases

immune system
• those double negative (DN) 3 cells that are able to develop into DN4 cells, exhibit increased apoptosis compared to controls
• decrease in total thymocyte number at 4-6 weeks of age
• 10-fold reduction in the number of alpha/beta TCR+ thymocytes
• double negative (DN) thymocytes fail to develop into large active double positive thymocytes
• accumulation of cells in the CD44-CD25+ DN3 stage and decreased CD44-CD25- DN4 cells, indicating a partial arrest at the DN3 to DN4 transition
• reduction in the CD4/CD8 ratio (1.33 vs 3-4 in controls)
• variable numbers of total SP CD8 cell numbers, with a decrease in most cases but increases in other cases

cellular
• those double negative (DN) 3 cells that are able to develop into DN4 cells, exhibit increased apoptosis compared to controls

endocrine/exocrine glands
• decrease in total thymocyte number at 4-6 weeks of age
• 10-fold reduction in the number of alpha/beta TCR+ thymocytes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory