Phenotypes Associated with This Genotype

Genotype
MGI:2683967

• Allelic Composition: Gata3^tm1Iho/Gata3^tm1Iho; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:86996 )

• thymocytes do not mature to the single positive stage

decreased CD4-positive, alpha-beta T cell number ( J:86996 )

• percentage of single positive CD4 thymocytes is reduced from 10-15% in controls to 3% or less in mutants

immune system

abnormal T cell differentiation ( J:86996 )

• thymocytes do not mature to the single positive stage

decreased CD4-positive, alpha-beta T cell number ( J:86996 )

• percentage of single positive CD4 thymocytes is reduced from 10-15% in controls to 3% or less in mutants