hematopoietic system
• increased apoptosis at double negative T cell stage
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• block at the double-negative stage between DN2 and DN3
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• decreased number of peripheral T cells
• detected peripheral T cells did not undergo cre-mediated recombination
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• reduction of the total number of thymocytes
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• reduction of double-negative cells in DN3 and DN4 subsets, but not in DN1 or DN2 subsets
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immune system
• increased apoptosis at double negative T cell stage
|
• block at the double-negative stage between DN2 and DN3
|
• decreased number of peripheral T cells
• detected peripheral T cells did not undergo cre-mediated recombination
|
• reduction of the total number of thymocytes
|
• reduction of double-negative cells in DN3 and DN4 subsets, but not in DN1 or DN2 subsets
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cellular
• increased apoptosis at double negative T cell stage
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endocrine/exocrine glands
• reduction of the total number of thymocytes
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