Phenotypes Associated with This Genotype

Genotype
MGI:2684221

• Allelic Composition: Med1^tm1Mpk/Med1^tm1Mpk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:86857 )

• all were necrotic by E14.0

• death due to hepatic hemorrhagic necrosis and poor myocardial development

cardiovascular system

abnormal heart morphology ( J:86857 )

• by E13.5 heart is very degenerate

trabecula carnea hypoplasia ( J:86857 )

• by E12.5

thin ventricular wall ( J:86857 )

• at the apex by E12.5

• some peripheral compaction

hematopoietic system

increased nucleated erythrocyte cell number ( J:86857 )

• by E11.25 excessive nucleated erythrocytes in dilated sinusoids of liver

limbs/digits/tail

abnormal limb morphology ( J:86857 )

• limb development a day behind by E13.5

muscle

trabecula carnea hypoplasia ( J:86857 )

• by E12.5

vision/eye

abnormal eye development ( J:86857 )

• eye development delayed about a day by E13.5

embryo

embryonic growth retardation ( J:86857 )

• by E13.5 severe growth retardation could be detected

growth/size/body

embryonic growth retardation ( J:86857 )

• by E13.5 severe growth retardation could be detected