Phenotypes Associated with This Genotype

Genotype
MGI:2686835

• Allelic Composition: Phox2b^Dilp1/Phox2b⁺
• Genetic Background: involves: BALB/cAnN * C3H/HeN

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:75964 )

• abnormal Mendelian ratios suggested that some heterozygous mice die before weaning

vision/eye

impaired pupillary reflex ( J:91199 )

• exhibit no pupillary response to light

• pupils fail to constrict in response to the parasympathetic agonist, carbachol

abnormal eye morphology ( J:75964 )

mydriasis ( J:75964 , J:91199 )

behavior/neurological

impaired pupillary reflex ( J:91199 )

• exhibit no pupillary response to light

• pupils fail to constrict in response to the parasympathetic agonist, carbachol

nervous system

abnormal ciliary ganglion morphology ( J:91199 )

• exhibit severe atrophy of the ciliary ganglia at E13.5

• however, the superior cervical ganglion is normal