Phenotypes Associated with This Genotype

Genotype
MGI:3026747

• Allelic Composition: Sox10^Dom/Sox10⁺
• Genetic Background: involves: C57BL/6JLe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:7688 )

• Background Sensitivity: survivability depends on genetic background with few mice surviving to weaning and dying soon thereafter on C57BL/6 and and 70 percent weaned from a B6C3 hybrid background

pigmentation

variable body spotting ( J:7688 )

• on belly and feet

digestive/alimentary system

megacolon ( J:7688 )

• distended colon is evident by 10 days of age

• myenteric ganglion cells of the midportion of the colon are reduced by 90 percent and are virtually absent in the distal one-half of the colon

integument

variable body spotting ( J:7688 )

• on belly and feet