Phenotypes Associated with This Genotype

Genotype
MGI:3027901

• Allelic Composition: Gli3^Pdn/Gli3^Pdn
• Genetic Background: involves: Jcl:ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

absent pineal gland ( J:17581 )

mortality/aging

postnatal lethality ( J:12736 )

• mice die within 2 days of birth

nervous system

abnormal radial glial cell morphology ( J:43330 )

• abnormal radial glial fibers are arranged in an irregular pattern compared to in wild-type mice

abnormal neuronal migration ( J:43330 )

absent pineal gland ( J:17581 )

hydrocephaly ( J:17581 , J:38885 )

absent hippocampal commissure ( J:38885 )

• mice are deficient in the commissure anterior, fornix, and commissura fornicis unlike wild-type mice

absent anterior commissure ( J:17581 , J:38885 )

• the fiber of the anterior commissure does not decussate on day 14 of gestation (J:17581)

• lack of massa commissuralis on day 15 of gestation (J:17581)

abnormal hypothalamus morphology ( J:17581 )

• regression of hypothalamus

abnormal thalamus morphology ( J:17581 )

• regression of thalamus

abnormal cerebral hemisphere morphology ( J:38885 )

• mice exhibit expansion of cerebrum compared with wild-type mice

• 8 of 10 mice exhibit fissuration of cerebral hemisphere unlike wild-type mice

• mice exhibit an expansion of ventriculus lateralis, tertius, and quartus, and aquaeductus cerebri are expanded compared with wild-type mice

abnormal hippocampus development ( J:17581 , J:38885 )

• hippocampal primordia and posterior of the telencephalon show wavy and/or rosette-like structures on day 14 of gestation (J:17581)

• pyramidal layers in regio superior and inferior are disorganized compared to in wild-type mice (J:38885)

absent corpus callosum ( J:17581 , J:38885 )

abnormal hippocampal fornix morphology ( J:17581 )

• absent

abnormal hippocampus pyramidal cell layer ( J:17581 )

• disorganized pyramidal layers

abnormal cerebral cortex morphology ( J:43330 )

• mice exhibit abnormal fissures and proturberances in the caudo-dorsal cortex compared to in wild-type mice

abnormal stratification in cerebral cortex ( J:38885 )

thin cerebral cortex ( J:43330 )

absent olfactory bulb ( J:17581 , J:38885 , J:43330 )

• olfactory bulb is never induced from the telencephalon (J:17581)

exencephaly ( J:12736 )

• observed in 20.7% of mice

abnormal olfactory nerve morphology ( J:17581 , J:38885 )

• olfactory nerve never attaches to the rostroventral telencephalon (J:17581)

• mice exhibit an irregular mass of the olfactory nerve on the cribriform plate unlike in wild-type mice (J:38885)

encephalomeningocele ( J:17581 )

• protrusion of cortical tissue

spongiform encephalopathy ( J:17581 , J:38885 )

• pyknotic and spongy degeneration were observed in the septal nucleus and the mesencephalon around the aqueduct of Sylvius at E16, the periventricular thalamus and hypothalamus at E18 and the corpus callosum and fimbria hippocampi at birth (J:17581)

• of the periventricular white matter at the posterior horn of the lateral ventricle in some mice (J:38885)

limbs/digits/tail

abnormal digit morphology ( J:12736 )

• displayed an extra tab on the postaxial side of the forelimb

polydactyly ( J:12736 )

• 2 to 3 extra preaxial digits on the forelimbs

• 1 to 3 extra preaxial digits on the hindlimbs

short fibula ( J:12736 )

• however the radii and ulnae are of normal length

short tibia ( J:12736 )

skeleton

short fibula ( J:12736 )

• however the radii and ulnae are of normal length

short tibia ( J:12736 )

split sternal manubrium ( J:12736 )

• bifurcation of the manubrium

synostosis ( J:12736 )

vision/eye

eyelids open at birth ( J:12736 )

• observed in 12.1% of mice

digestive/alimentary system

cleft palate ( J:12736 )

• observed in 12.1% of mice

craniofacial

cleft palate ( J:12736 )

• observed in 12.1% of mice

cellular

abnormal radial glial cell morphology ( J:43330 )

• abnormal radial glial fibers are arranged in an irregular pattern compared to in wild-type mice

abnormal neuronal migration ( J:43330 )

growth/size/body

cleft palate ( J:12736 )

• observed in 12.1% of mice