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Phenotypes Associated with This Genotype
Genotype
MGI:3033580
Allelic
Composition
Timp1tm1Pds/Y
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp1tm1Pds mutation (1 available); any Timp1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mutants form significantly larger aneurysms than wild-type after elastase infusion to induce aneurysm formation (to model abdominal aortic aneurysm) (J:101938)
• mutants, unlike wild-type, also develop aneurysms following saline injection (J:101938)
• hemizygotes show increased and continued progression of aneurysm formation compared with wild-type in a thoracic aortic aneurysm model (induced by calcium chloride treatment) (J:102182)
• increased left ventricle end-diastolic pressure and volume vs. wild-type controls
• exhibit accelerated myocardial remodeling after myocardial infarction (coronary ligation) as indicated by increased left ventricular (LV) dilatation and LV dysfunction the accelerated remodeling can be rescued by MMP inhibition

endocrine/exocrine glands
• increased testicular weight at day 21 after birth

growth/size/body
N
• body weight equivalent to controls at same age

homeostasis/metabolism
• exhibit accelerated myocardial remodeling after myocardial infarction (coronary ligation) as indicated by increased left ventricular (LV) dilatation and LV dysfunction the accelerated remodeling can be rescued by MMP inhibition
• only at day 21 after birth

reproductive system
• increased testicular weight at day 21 after birth


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory