cardiovascular system
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• mutants form significantly larger aneurysms than wild-type after elastase infusion to induce aneurysm formation (to model abdominal aortic aneurysm)
(J:101938)
• mutants, unlike wild-type, also develop aneurysms following saline injection
(J:101938)
• hemizygotes show increased and continued progression of aneurysm formation compared with wild-type in a thoracic aortic aneurysm model (induced by calcium chloride treatment)
(J:102182)
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• increased left ventricle end-diastolic pressure and volume vs. wild-type controls
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• exhibit accelerated myocardial remodeling after myocardial infarction (coronary ligation) as indicated by increased left ventricular (LV) dilatation and LV dysfunction
the accelerated remodeling can be rescued by MMP inhibition
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endocrine/exocrine glands
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• increased testicular weight at day 21 after birth
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growth/size/body
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• body weight equivalent to controls at same age
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homeostasis/metabolism
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• exhibit accelerated myocardial remodeling after myocardial infarction (coronary ligation) as indicated by increased left ventricular (LV) dilatation and LV dysfunction
the accelerated remodeling can be rescued by MMP inhibition
|
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• only at day 21 after birth
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reproductive system
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• increased testicular weight at day 21 after birth
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