Phenotypes Associated with This Genotype

Genotype
MGI:3033580

• Allelic Composition: Timp1^tm1Pds/Y
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

aortic aneurysm ( J:101938 , J:102182 )

♂ • mutants form significantly larger aneurysms than wild-type after elastase infusion to induce aneurysm formation (to model abdominal aortic aneurysm) (J:101938)

♂ • mutants, unlike wild-type, also develop aneurysms following saline injection (J:101938)

♂ • hemizygotes show increased and continued progression of aneurysm formation compared with wild-type in a thoracic aortic aneurysm model (induced by calcium chloride treatment) (J:102182)

increased left ventricle diastolic pressure ( J:60524 )

♂ • increased left ventricle end-diastolic pressure and volume vs. wild-type controls

abnormal response to cardiac infarction ( J:95572 )

♂ • exhibit accelerated myocardial remodeling after myocardial infarction (coronary ligation) as indicated by increased left ventricular (LV) dilatation and LV dysfunction the accelerated remodeling can be rescued by MMP inhibition

endocrine/exocrine glands

increased testis weight ( J:49303 )

♂ • increased testicular weight at day 21 after birth

growth/size/body

growth/size/body region phenotype ( J:49303 )

♂N • body weight equivalent to controls at same age

homeostasis/metabolism

abnormal response to cardiac infarction ( J:95572 )

♂ • exhibit accelerated myocardial remodeling after myocardial infarction (coronary ligation) as indicated by increased left ventricular (LV) dilatation and LV dysfunction the accelerated remodeling can be rescued by MMP inhibition

increased circulating testosterone level ( J:49303 )

♂ • only at day 21 after birth

reproductive system

increased testis weight ( J:49303 )

♂ • increased testicular weight at day 21 after birth