Analysis Tools
mortality/aging
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• by 13.5 dpc, most mutant embryos had died, but a few embryos with severe edema were still alive
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cardiovascular system
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• at E10.5 segements of the dorsal aorta are regressed
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• at E9.5 all embryos (N = 5) exhibited severe regression of the arch artery system (arch arteries 1 - 3 are normally bilaterally symmetrical at this time)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, 15 out of 22 embryos lack the right and left arch arteries 4
• at E 12.5 the left arch artery 4, which normally forms the arch of the aorta is absent and the arch of the aorta forms on the right side (15 out of 21)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, all embryos (N = 22) lack the right and left arch arteries 6
• at E12.5 all embryos (N = 21) lack the left arch artery 6
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• at E10.5, some embryos missing arch artery 4 also lack the arch artery 3 on either side
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• the distal end of the pulmonary channel merges with the aortic arch
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• at E12.5 the left subclavian artery arises from the right sided arch of the aorta
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• right arotic arch is observed in some mutants
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• observed in some mutants
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• capillary invasion is absent from the central nervous system of mutants at E10.5
• at E12.5 little vascularization is seen in the neocortex, dorsal part of the midbrain, spinal cord, and sensory ganglia
• at E12.5 abnormal capillaries, that are of large caliber, with few branches and often broken into small spherical segments, are present in the diencephalon, ventral midbrain, hindbrain, and ventral spinal cord
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• at E12.5 the yolk sac of mutants is as well vascularized as that of wild-types however the vascular networks are abnormal
• the large vessels meander and are often divided into small vessels that anastomose
• capillary networks in the yolk sac are sparse
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• at E12.5 seperation of the truncus arteriosus is incomplete (5 out of 6)
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embryo
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• at E9.5 all embryos (N = 5) exhibited severe regression of the arch artery system (arch arteries 1 - 3 are normally bilaterally symmetrical at this time)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, 15 out of 22 embryos lack the right and left arch arteries 4
• at E 12.5 the left arch artery 4, which normally forms the arch of the aorta is absent and the arch of the aorta forms on the right side (15 out of 21)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, all embryos (N = 22) lack the right and left arch arteries 6
• at E12.5 all embryos (N = 21) lack the left arch artery 6
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• at E10.5, some embryos missing arch artery 4 also lack the arch artery 3 on either side
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• at E12.5 the yolk sac of mutants is as well vascularized as that of wild-types however the vascular networks are abnormal
• the large vessels meander and are often divided into small vessels that anastomose
• capillary networks in the yolk sac are sparse
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craniofacial
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• at E9.5 all embryos (N = 5) exhibited severe regression of the arch artery system (arch arteries 1 - 3 are normally bilaterally symmetrical at this time)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, 15 out of 22 embryos lack the right and left arch arteries 4
• at E 12.5 the left arch artery 4, which normally forms the arch of the aorta is absent and the arch of the aorta forms on the right side (15 out of 21)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, all embryos (N = 22) lack the right and left arch arteries 6
• at E12.5 all embryos (N = 21) lack the left arch artery 6
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• at E10.5, some embryos missing arch artery 4 also lack the arch artery 3 on either side
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