Phenotypes Associated with This Genotype

Genotype
MGI:3037192

• Allelic Composition: Crhr1^tm1Wrst/Crhr1⁺
• Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased behavioral withdrawal response ( J:76022 )

decreased anxiety-related response ( J:76022 )

• compared with homozygous mutant and wild-type mice, heterozygous mutant mice displayed an intermediate reduction in anxiety-related performance under ethanol-withdrawal conditions in the light-dark box, suggesting a gene-dosage effect

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:76022 )

N • heterozygous mutant males and females displayed normal basal levels of POMC1 (ACTH)

N • heterozygous mutant mice displayed a normal HPA axis response to forced-swim stress: similar to wild-type, heterozygous females and males responded by significantly increasing circulating levels of POMC1 (ACTH)