Analysis Tools
mortality/aging
|
• a large portion of embryos are resorbed after E10, though some mice develop normally and survive to adulthood
|
cardiovascular system
| N |
• mice that survive to adulthood exhibit normal platelet number and function, coagulation parameters, basal heart rate, and arterial blood pressure
(J:38032)
• mutants exhibit normal pulmonary vasoreactivity to vasoactive mediators
(J:124465)
|
|
• cell density is greater in normal carotids from mutants than in wild-type mice
|
|
• mutants exhibit a reduction of the hypertensive response to the selective thrombin receptor activating peptide, SFLLRN-NH2, before and after L-NAME (an inhibitor of nitric oxide synthesis) and absence of hypertension in the presence of L-NAME
|
|
• mutants show absence of an arterial pressure response to the selective thrombin receptor activating peptide, TFLLRNPNDK-NH2
|
|
• the hypertensive response and heart rate decrease in response to TFLLRNPNDK, a F2r (PAR-1) selective activating peptide, is absent
• SFLLRN, a nonselective receptor activating peptide, was able to induce hypotension in mutants as in wild-type mice but the heart rate decrease and secondary hypotension following L-NAME are absent
|
|
• the thrombin-induced increase in pulmonary microvessel permeability seen in controls is absent in mutants
|
|
• vessel diameter is unchanged and lumen diameter decreases following vascular injury unlike in wild-type mice in which vessel and lumen diameters increase following injury
• area of neointima formation following vascular injury is slightly less than in wild-type mice
• however, medial cell loss, incidence of thrombosis, endothelial regrowth, and medial thickening after injury are similar to wild-type
|
reproductive system
|
• matings between homozygous mice occur infrequently and produce less than 3 offspring
|
homeostasis/metabolism
|
• vessel diameter is unchanged and lumen diameter decreases following vascular injury unlike in wild-type mice in which vessel and lumen diameters increase following injury
• area of neointima formation following vascular injury is slightly less than in wild-type mice
• however, medial cell loss, incidence of thrombosis, endothelial regrowth, and medial thickening after injury are similar to wild-type
|
digestive/alimentary system
|
• mutants have a lower baseline short-circuit current in the colon than wild-type mice but no difference in the short-circuit current response to electrical field stimulation, indicating abnormal basal ion secretion in the colon
|
|
• trinitrobenzene sulfonic acid (TNBS) induced colitis is less severe in mutants than in wild-type mice
|
immune system
|
• absence of human trypsin IV and rat p23 induced edema and granulocyte infiltration after intraplantar injection
|
|
• trinitrobenzene sulfonic acid (TNBS) induced colitis is less severe in mutants than in wild-type mice
|
