Phenotypes Associated with This Genotype

Genotype
MGI:3039490

• Allelic Composition: Tg(Apcs-Lep)1Yog/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased brown adipose tissue amount ( J:57075 )

• brown adipose tissue develops normally but disappears by 3 weeks of age

decreased white adipose tissue amount ( J:57075 )

• transgenic develop no white adipose tissue

behavior/neurological

abnormal food intake ( J:57075 )

• transgenic mice eat less than non-transgenic mice

endocrine/exocrine glands

small pancreatic islets ( J:57075 )

• the size of the islets is markedly reduced compared to pair-fed non-transgenic littermates

growth/size/body

decreased body weight ( J:57075 )

• 4-week old transgenic mice weigh significantly less than non-transgenic mice

homeostasis/metabolism

abnormal glucose homeostasis ( J:57075 )

decreased circulating insulin level ( J:57075 )

• insulin concentrations are significantly decreased compared to pair-fed non-transgenic littermates

decreased liver glycogen level ( J:57075 )

• at 17 weeks the liver glycogen content is significantly less in transgenic mice than in non-transgenic littermates

increased insulin sensitivity ( J:57075 )

• after glucose injection the increase in serum glucose levels is less than that in fed non-transgenic littermates

• after insulin injection the hyper glycemic response is seen faster in transgenic mice than in non-transgenic littermates

abnormal lipid level ( J:57075 )

decreased circulating triglyceride level ( J:57075 )

• plasma triglyceride levels are significantly decreased compared to pair-fed non-transgenic littermates

decreased liver triglyceride level ( J:57075 )

• liver triglyceride levels are significantly decreased compared to pair-fed non-transgenic littermates

liver/biliary system

decreased liver glycogen level ( J:57075 )

• at 17 weeks the liver glycogen content is significantly less in transgenic mice than in non-transgenic littermates

decreased liver triglyceride level ( J:57075 )

• liver triglyceride levels are significantly decreased compared to pair-fed non-transgenic littermates

decreased liver weight ( J:57075 )

• at 17 weeks the liver weight in transgenic mice is significantly less than that in pair-fed non-transgenic littermates