Phenotypes Associated with This Genotype

Genotype
MGI:3040184

• Allelic Composition: Ticam2^tm1Aki/Ticam2^tm1Aki
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system physiology ( J:86256 )

• defects in MyD88-independent TLR4 signaling resulting in impaired splenocyte proliferation and upregulation of surface molecules

• impaired responses to LPS stimulation

decreased interleukin-6 secretion ( J:86256 )

• reduced IL-6 production when induced with LPS

increased susceptibility to Coronaviridae infection ( J:270045 )

• increased susceptibility to SARS-CoV MA15

• greater SARS-CoV induced weight loss than control mice

• pulmonary hemorrhage scores were significantly higher in mutant mice at 4 d postinfection compared to controls

• virus load is significantly higher at day 2 postinfection compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coronavirus infectious disease		DOID:0080599		J:270045