Phenotypes for Tcf3 Tcf12 MGI:3040599 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tcf12^tm1Zhu/Tcf12⁺ Tcf3^tm1Wein/Tcf3⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12^tm1Zhu mutation (0 available); any Tcf12 mutation (75 available)
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:43324 )

• most homozygotes died within two weeks of birth

growth/size/body

postnatal growth retardation ( J:43324 )

• evident after birth

hematopoietic system

decreased pro-B cell number ( J:43324 )

• 70% reduction in the number of pro-B cells

immune system

decreased pro-B cell number ( J:43324 )

• 70% reduction in the number of pro-B cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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