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Phenotypes Associated with This Genotype
Genotype
MGI:3040601
Allelic
Composition		 Tcf12tm1Zhu/Tcf12+
Tcf4tm1Zhu/Tcf4+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (75 available)
Tcf4tm1Zhu mutation (0 available); any Tcf4 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:43324 )
• most homozygotes died within two weeks of birth

growth/size/body
postnatal growth retardation ( J:43324 )
• evident after birth

hematopoietic system
decreased pro-B cell number ( J:43324 )
• 50% reduction in the number of pro-B cells

immune system
decreased pro-B cell number ( J:43324 )
• 50% reduction in the number of pro-B cells

nervous system
nervous system phenotype ( J:125313 )
N
• the pontine nucleus develops normally

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory