Phenotypes Associated with This Genotype

Genotype
MGI:3041080

• Allelic Composition: Podxl^tm1Kmn/Podxl^tm1Kmn
• Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Edema in Podxl^tm1Kmn/Podxl^tm1Kmn mice

mortality/aging

neonatal lethality, complete penetrance ( J:70294 )

• homozygotes die within 24 hours of birth

homeostasis/metabolism

hydrops fetalis ( J:70294 )

• mild to severe edema after E15 in about 25% of homozygotes

• edema usually appears as subdermal swelling as early as E15 and a mildly turgid trunk and appendages at E18

growth/size/body

omphalocele ( J:70294 )

• ~30% of mice are born with an omphalocele or herniation of the gut into the umbilical cord

• 13 or 14 of embryos exhibit omphalocele up to E17, unlike wild-type embryos which show complete resolution of physiologic omphalocele by E15 or E16; ~70% of these mice resolve the omphalocele prior to birth

renal/urinary system

absent podocyte foot process ( J:70294 )

• lack foot processes

absent podocyte slit diaphragm ( J:70294 )

• lack slit diaphragms

anuria ( J:70294 )

• newborn mice lack urine in the bladder

cardiovascular system

increased systemic arterial blood pressure ( J:70294 )

• measured in embryos as a 15 fold increase in RBC released from a severed umbilical artery as compared to control embryos