Phenotypes Associated with This Genotype

Genotype
MGI:3041528

• Allelic Composition: Prkar1b^tm1Gsm/Prkar1b^tm1Gsm
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:43080 )

N • no difference from controls in response to acute thermal and mechanical pain

N • indices of pain produced by nerve injury similar to controls

abnormal nociception after inflammation ( J:43080 )

• reduced pain after intraplanar formalin injection

increased thermal nociceptive threshold ( J:43080 )

• while baseline response to thermal stimulus was similar to controls, mutant mice showed less thermal allodynia after PGE2 injection compared to controls

immune system

decreased inflammatory response ( J:43080 )

• reduced plasma extravasation in response to intradermal capsaicin injection in the paw