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Phenotypes Associated with This Genotype
Genotype
MGI:3041951
Allelic
Composition
Prkcbtm1Tara/Prkcb+
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcbtm1Tara mutation (0 available); any Prkcb mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• compared to controls, reduced humoral response to T cell-independent antigen (NP-Ficoll), but not T cell-dependent antigen (NP-chick gamma-globulin conjugate)
• greater response than homozygous mutant mice, suggestive of gene dosage effects
• IgG3 slightly reduced, compared to controls, but greater than homozygous mutant mice, suggestive of gene dosage phenomenon
• slightly reduced, compared to controls, but greater than homozygous mutant mice, suggestive of gene dosage phenomenon

hematopoietic system
• IgG3 slightly reduced, compared to controls, but greater than homozygous mutant mice, suggestive of gene dosage phenomenon
• slightly reduced, compared to controls, but greater than homozygous mutant mice, suggestive of gene dosage phenomenon


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/17/2024
MGI 6.24
The Jackson Laboratory