Phenotypes Associated with This Genotype

Genotype
MGI:3042106

• Allelic Composition: Prkcg^tm1Stl/Prkcg^tm1Stl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to alcohol ( J:25061 )

• reduced sensitivity to ethanol on loss of righting reflex and hypothermia

• no such alterations in sensitivity to flunitrazepam or pentobarbital

abnormal nociception after inflammation ( J:25061 )

• attenuated response during the second, prolonged phase of nociceptive pain after formalin-injection into paw

abnormal pain threshold ( J:25061 )

• failed to develop neuropathic pain (induced by thermal or mechanical means) after partial sciatic nerve section

• reduced neurochemical changes in the spinal cord after nerve injury

• normal response to acute pain (thermal or mechanical) stimuli in the absence of nerve injury

immune system

decreased inflammatory response ( J:25061 )

• reduced plasma extravasation in response to intradermal capsaicin injection in the paw