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Phenotypes Associated with This Genotype
Genotype
MGI:3042109
Allelic
Composition
Prkcgtm1Stl/Prkcgtm1Stl
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcgtm1Stl mutation (1 available); any Prkcg mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• ingested more ethanol than controls, but no greater consumption of liquid volume
• while both males and females consumed more ethanol than controls, females consumed more than males
• lack of tolerance to sedative-hypnotic effects of chronic (10 day) ethanol diet
• developed chronic hypothermia tolerance after 10 day ethanol diet
• in elevated plus-maze, black/white box, and mirrored chamber
• baseline locomotor activity is similar to controls
• greater behavioral impulsivity in appetitive-signaled nosepoke test

taste/olfaction
N
• saccharin preference similar to controls
• nicotine consumption similar to controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory