Phenotypes Associated with This Genotype

Genotype
MGI:3043032

• Allelic Composition: Drgx^tm1And/Drgx^tm1And
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:70560 )

• 100% of pups are dead by 3 weeks of age

embryo

abnormal embryonic tissue morphology ( J:70560 )

• embryos showed delayed projections of primary sensory afferents in the dorsal horn, selectively affecting cutaneous afferents

• normal differentiation and development of sensory neurons of the dorsal root ganglia

growth/size/body

decreased body weight ( J:70560 )

• weighed less than wild-type or heterozygous littermate controls

nervous system

abnormal sensory neuron innervation pattern ( J:70560 )

• embryos showed delayed projections of primary sensory afferents in the dorsal horn, selectively affecting cutaneous afferents

• normal differentiation and development of sensory neurons of the dorsal root ganglia