Phenotypes Associated with This Genotype

Genotype
MGI:3043966

• Allelic Composition: Gjb6^tm1Kwi/Gjb6^tm1Kwi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:89971 )

• homozygous mice spend less time in the center and more time in the corners in an open field and cross the center of an open field with higher velocity than wild-type mice

• homozygous mice visit a familiar object displaced to the center of an open field less frequently than wild-type mice

• no difference was detected in a graded anxiety test between homozygous and wild-type mice

decreased vertical activity ( J:89971 )

• during open field and object exploration tests homozygous mice spent less time rearing

nervous system

nervous system phenotype ( J:89971 )

N • no gross abnormalities were detected in sections from various brain regions

abnormal nervous system physiology ( J:89971 )

• choline levels in the ventral striatum are increased