Phenotypes Associated with This Genotype

Genotype
MGI:3044931

• Allelic Composition: Tg(Dll1-Tbx18)20Akis/Tg(Dll1-Tbx18)20Akis
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

decreased embryo size ( J:90513 )

• body length is reduced in homozygous embryos

abnormal dorsal-ventral polarity of the somites ( J:90513 )

• marker expression patterns indicate that anterior-posterior polarity of the somites and lateral sclerotome is abnormal

growth/size/body

decreased embryo size ( J:90513 )

• body length is reduced in homozygous embryos

skeleton

absent proximal rib ( J:90513 )

• the proximal ribs are largely reduced or absent all along the vertebral column

abnormal thoracic cage shape ( J:90513 )

• a distorted rib cage is seen in homozygous mice

small thoracic cage ( J:90513 )

• a small rib cage is seen in homozygous mice

lordosis ( J:90513 )

• severe lordosis of the vertebral column is seen in the thoracic region

abnormal vertebrae morphology ( J:90513 )

abnormal vertebral pedicle morphology ( J:90513 )

• pedicles are largely reduced or absent all along the vertebral column

nervous system

abnormal spinal nerve morphology ( J:90513 )

• at E10.5 spinal nerve appear less bundled with some single axons projecting laterally away from the bundle