Phenotypes for Mpl Myb MGI:3045896 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mpl^tm1Wsa/Mpl^tm1Wsa Myb^Plt3/Myb⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpl^tm1Wsa mutation (1 available); any Mpl mutation (47 available)
Myb^Plt3 mutation (0 available); any Myb mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal megakaryocyte differentiation ( J:89601 )

• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen

abnormal definitive hematopoiesis ( J:89601 )

• numbers of most progenitor cell lines are unchanged

abnormal thrombopoiesis ( J:89601 )

thrombocytosis ( J:89601 )

• amelioration of thrombocytopenia compared to Mpl^tm1Wsa but not to wild-type

cellular

abnormal megakaryocyte differentiation ( J:89601 )

• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen

immune system

abnormal thrombopoiesis ( J:89601 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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