Phenotypes Associated with This Genotype

Genotype
MGI:3046636

• Allelic Composition: Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr; Tg(KRT14-cre/ERT2)1Ipc/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:91054 )

• survived at least 6 months when not treated with tamoxifen which causes the mice to become sickly

neoplasm

preneoplasia ( J:91054 )

• benign proliferations derived from hair follicles and follicular cysts

• tamoxifen treatment accelerated cyst formation

integument

abnormal hair growth ( J:91054 )

sparse hair ( J:91054 )

• sparse hair becoming more severe with age

abnormal nail morphology ( J:91054 )

• abnormal growths under the nails

abnormal hair follicle morphology ( J:91054 )

• maintained in proliferative state