Phenotypes for Nfkb1 Rela Tnf MGI:3046863 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nfkb1^tm1Bal/Nfkb1^tm1Bal Rela^tm1Bal/Rela^tm1Bal Tnf^tm1Ljo/Tnf^tm1Ljo
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1^tm1Bal mutation (3 available); any Nfkb1 mutation (102 available)
Rela^tm1Bal mutation (1 available); any Rela mutation (28 available)
Tnf^tm1Ljo mutation (3 available); any Tnf mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:91366 )

• triple homozygous pups die within 12 hours of birth

prenatal lethality, incomplete penetrance ( J:91366 )

• fewer than expected triple homozygous mutants are found at birth

integument

thin epidermis ( J:91366 )

• the epidermis is marginally thinner

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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