Phenotypes Associated with This Genotype

Genotype
MGI:3047405

• Allelic Composition: Gnai2^tm1Lbi/Gnai2^tm1Lbi
• Genetic Background: either: 129 or (involves: 129S7/SvEvBrd * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased thymocyte number ( J:24434 )

• increase of single positive thymocytes, evident at 2 weeks of age and preceding the onset of inflammatory bowel disease

• 3- to 5-fold increased proliferative response to T cell receptor stimuli

increased granulocyte number ( J:24434 )

• 20-fold increase in the number of granulocytes in spleens and peripheral blood

increased IgG level ( J:24434 )

• elevated in the large intestine, and more modestly in the small intestine

• correlative to increases observed in patients with inflammatory bowel disease

increased IgM level ( J:24434 )

• elevated in the large, but not small, intestine

• correlative to increases observed in patients with inflammatory bowel disease

immune system

increased thymocyte number ( J:24434 )

• increase of single positive thymocytes, evident at 2 weeks of age and preceding the onset of inflammatory bowel disease

• 3- to 5-fold increased proliferative response to T cell receptor stimuli

increased granulocyte number ( J:24434 )

• 20-fold increase in the number of granulocytes in spleens and peripheral blood

increased IgG level ( J:24434 )

• elevated in the large intestine, and more modestly in the small intestine

• correlative to increases observed in patients with inflammatory bowel disease

increased IgM level ( J:24434 )

• elevated in the large, but not small, intestine

• correlative to increases observed in patients with inflammatory bowel disease

abnormal cytokine secretion ( J:24434 )

• elevated cytokine levels produced by both thymocytes and peripheral T cells, indicating that mature thymocytes migrate properly to spleen and lymph nodes and retain a hyper-responsive cytokine production profile

endocrine/exocrine glands

increased thymocyte number ( J:24434 )

• increase of single positive thymocytes, evident at 2 weeks of age and preceding the onset of inflammatory bowel disease

• 3- to 5-fold increased proliferative response to T cell receptor stimuli