Phenotypes Associated with This Genotype

Genotype
MGI:3050669

• Allelic Composition: Lepr^db-rtnd/Lepr^db-rtnd
• Genetic Background: involves: C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:83762 )

• mice have enlarged pancreatic islets with well granulated and vascularized beta cells in mice on a predominantly B6 background but de-grangulated and hypertrophied beta cells on a mainly CBA background

growth/size/body

obese ( J:83762 )

• both males and females become morbidly obese by 12 weeks of age

homeostasis/metabolism

hyperglycemia ( J:83762 )

• on a predominantly B6 background females are normoglycemic while males are mildly hyperglycemic

• on a mainly CBA background both males and females were hyperglycemic

increased circulating insulin level ( J:83762 )

• higher insulin levels are seen in all animals, particularly on a predominantly B6 background