Phenotypes for Shh Tg(SFTPC-rtTA)5Jaw Tg(tetO-cre)1Jaw MGI:3051583 MGI Mouse

neonatal lethality, complete penetrance ( J:91723 )

• mutants die shortly after birth when doxycycline is administered throughout gestation

• in the absence of doxycycline mutants are viable

abnormal lung morphology ( J:91723 )

• lung and airway malformations are seen when doxycycline exposure occurs between E0.5 and E13.5

• doxycycline exposure after E13.5 does not result in any pulmonary or extrapulmonary abnormalities

lung cyst ( J:91723 )

• cysts that contain neuroepithelial cells are seen in the peripheral lung tissue

abnormal branching involved in lung morphogenesis ( J:91723 )

• branching morphogenesis is abnormal

pulmonary hypoplasia ( J:91723 )

• lungs are hypoplastic when doxycycline is administered throughout gestation

abnormal bronchus morphology ( J:91723 )

• peripheral tubule dilation is seen after doxycycline exposure

abnormal trachea morphology ( J:91723 )

• tracheal abnormalities are seen

• doxycycline exposure before E8.5 or after E13.5 does not result in tracheal abnormalities

abnormal tracheal cartilage morphology ( J:91723 )

• the cartilaginous rings that normal surround the trachea are malformed with incomplete rings found along the ventral midline after doxycycline exposure

decreased tracheal cartilage ring number ( J:91723 )

• fewer cartilaginous rings are seen after doxycycline exposure