Phenotypes Associated with This Genotype

Genotype
MGI:3051585

• Allelic Composition: Shh^tm1Amc/Shh^tm1Amc; Tg(SFTPC-rtTA)5Jaw/0; Tg(tetO-Shh)1Jaw/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:91723 )

• mutants die shortly after birth even when doxycycline is administered throughout gestation

respiratory system

abnormal lung lobe morphology ( J:91723 )

• a significant increase in peripheral lung tissue and relatively normal branching morphogenesis are seen with doxycycline treatment; however, lobulation of the lungs is not restored

absent tracheal cartilage rings ( J:91723 )

• doxycycline treatment does not restore tracheal-bronchial cartilaginous ring formation

skeleton

absent tracheal cartilage rings ( J:91723 )

• doxycycline treatment does not restore tracheal-bronchial cartilaginous ring formation