Phenotypes Associated with This Genotype

Genotype
MGI:3051883

• Allelic Composition: Grap2^tm1Eac/Grap2^tm1Eac
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal double-negative T cell morphology ( J:92023 )

• the overall number of double negative T cells is unchanged, however the fraction of pro-T3 cells is increased and the fraction of pro-T4 cells only slightly decreased suggesting a partial block in the double negative to double positive transition

increased memory T cell number ( J:92023 )

• there is a 6 fold increase in the fraction of CD8+ cells that behave as memory T cells

decreased T cell number ( J:92023 )

• in the thymus the number of single positive T cells is decreased and the ratio of CD4⁺ to CD8⁺ is skewed with a relative increase in CD8⁺ cells

decreased thymocyte number ( J:92023 )

• the total number of thymocytes is significantly decreased in 8 - 10 week old mutants

increased activated T cell number ( J:92023 )

• there is a 6 fold increase in the fraction of CD4+ cells that behave as activated T cells

abnormal CD4-positive, alpha beta T cell morphology ( J:92023 )

• the number of CD4⁺ T cells in the spleen and lymph nodes is decreased to a greater extent than the number of CD8⁺ T cells at 8 - 10 weeks of age

• there is a 6 fold increase in the fraction of cells that behave as activated T cells

• proliferation and apoptosis are increased in peripheral CD4⁺ T cells but not in CD8⁺ T cells

hematopoietic system

abnormal double-negative T cell morphology ( J:92023 )

• the overall number of double negative T cells is unchanged, however the fraction of pro-T3 cells is increased and the fraction of pro-T4 cells only slightly decreased suggesting a partial block in the double negative to double positive transition

increased memory T cell number ( J:92023 )

• there is a 6 fold increase in the fraction of CD8+ cells that behave as memory T cells

decreased T cell number ( J:92023 )

• in the thymus the number of single positive T cells is decreased and the ratio of CD4⁺ to CD8⁺ is skewed with a relative increase in CD8⁺ cells

decreased thymocyte number ( J:92023 )

• the total number of thymocytes is significantly decreased in 8 - 10 week old mutants

increased activated T cell number ( J:92023 )

• there is a 6 fold increase in the fraction of CD4+ cells that behave as activated T cells

abnormal CD4-positive, alpha beta T cell morphology ( J:92023 )

• the number of CD4⁺ T cells in the spleen and lymph nodes is decreased to a greater extent than the number of CD8⁺ T cells at 8 - 10 weeks of age

• there is a 6 fold increase in the fraction of cells that behave as activated T cells

• proliferation and apoptosis are increased in peripheral CD4⁺ T cells but not in CD8⁺ T cells

endocrine/exocrine glands

decreased thymocyte number ( J:92023 )

• the total number of thymocytes is significantly decreased in 8 - 10 week old mutants