Phenotypes for Cblb Ubash3a Ubash3b MGI:3052005 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cblb^tm1Hua/Cblb^tm1Hua Ubash3b^tm1Jni/Ubash3b^tm1Jni Ubash3a^tm1Jni/Ubash3a^tm1Jni
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblb^tm1Hua mutation (0 available); any Cblb mutation (58 available)
Ubash3a^tm1Jni mutation (0 available); any Ubash3a mutation (33 available)
Ubash3b^tm1Jni mutation (0 available); any Ubash3b mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell proliferation ( J:89761 )

• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1^tm1Jni Ubash3a^tm1Jni double homozygotes or Cblb^tm1Hua homozygotes

increased susceptibility to experimental autoimmune encephalomyelitis ( J:89761 )

• the incidence and severity of experimental autoimmune encephalomyelitis is increased similar to the increase seen in Elf1^tm1Jni Ubash3a^tm1Jni double homozygotes

hematopoietic system

increased T cell proliferation ( J:89761 )

• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1^tm1Jni Ubash3a^tm1Jni double homozygotes or Cblb^tm1Hua homozygotes

cellular

increased T cell proliferation ( J:89761 )

• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1^tm1Jni Ubash3a^tm1Jni double homozygotes or Cblb^tm1Hua homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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