Analysis Tools
mortality/aging
|
• average life span is 90 days; longer on heterogeneous background and may reproduce
|
pigmentation
|
• appears uniform gray
|
head blaze
(
J:7723
)
belly spot
(
J:7723
)
|
• light ears are evident by postnatal day 3
• white feet and tail
|
behavior/neurological
|
• follow movement tremors
|
digestive/alimentary system
|
• at 3 weeks of age, mice present with abdominal distention due to intestinal gas, and watery feces
|
nervous system
|
• follow movement tremors
|
|
• severe vacuolation of gray (in neuropil) and white matter
• seen as early as 7 days of age
• vacuolation of white matter begins in spinal cord and follows in gray matter of brainstem, thalamus, and spinal cord
• superficial cerebral cortex, cerebellar cortex, and retina are not affected
|
demyelination
(
J:7723
)
|
• hypo- and dysmyelination is found
• delayed and hypomyelination found especially at root entry zones
• dysmyelination occurs as multiple exons enclosed in a single myelin sheath
|
integument
|
• appears uniform gray
|
head blaze
(
J:7723
)
belly spot
(
J:7723
)
|
• light ears are evident by postnatal day 3
• white feet and tail
|
