Phenotypes Associated with This Genotype

Genotype
MGI:3052995

• Allelic Composition: Ccr9^tm1.1Mal/Ccr9^tm1.1Mal
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased pro-B cell number ( J:72386 )

• fewer pre-pro B cells

• fewer CD4+ B220+ B cells in bone marrow, but numbers of mature B cells are not affected

abnormal T cell differentiation ( J:72386 )

• one day lag in the development of double positive cells in fetal thymus

abnormal leukocyte cell number ( J:72386 )

decreased T cell number ( J:72386 )

• 3-5 fold decrease in number of T cell receptor gamma/delta cells found in small intestine

• intraepithelial lymphocyte to epithelial cell ratio is decreased 2-fold in small intestine

decreased double-positive T cell number ( J:72386 )

• 3-fold fewer lymphoid cells from E14.5-E17.5, corrected by E18.5

• 15-20 fold fewer double positive cells at E16.5

increased T cell number ( J:72386 )

• 2-3 fold increase in peripheral T cell receptor gamma/delta cells found in lymph nodes and spleen

immune system

decreased pro-B cell number ( J:72386 )

• fewer pre-pro B cells

• fewer CD4+ B220+ B cells in bone marrow, but numbers of mature B cells are not affected

abnormal T cell differentiation ( J:72386 )

• one day lag in the development of double positive cells in fetal thymus

abnormal leukocyte cell number ( J:72386 )

decreased T cell number ( J:72386 )

• 3-5 fold decrease in number of T cell receptor gamma/delta cells found in small intestine

• intraepithelial lymphocyte to epithelial cell ratio is decreased 2-fold in small intestine

decreased double-positive T cell number ( J:72386 )

• 3-fold fewer lymphoid cells from E14.5-E17.5, corrected by E18.5

• 15-20 fold fewer double positive cells at E16.5

increased T cell number ( J:72386 )

• 2-3 fold increase in peripheral T cell receptor gamma/delta cells found in lymph nodes and spleen