Phenotypes Associated with This Genotype

Genotype
MGI:3053437

• Allelic Composition: Ceacam1^tm2Bcn/Ceacam1^tm2Bcn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to Coronaviridae infection ( J:92376 )

• complete resistance to infection with mouse hepatitis virus (MHV-59)

• mice do not develop liver lesions

• demyelination does not occur in spinal cord

digestive/alimentary system

abnormal colon morphology ( J:115838 )

• exhibit a 30% increase in the number of proliferative cells in the colon

• exhibit decreased apoptosis in the colonic villi

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:115838 )

• when treated with azoxymethane to induce colonic tumors, homozygotes develop greater number of tumors and tumor size is larger, indicating a more rapid progression in the tumor development; tumors are classified as intramucosal carcinomas

• however, homozygotes do not develop tumors spontaneously

neoplasm

increased incidence of tumors by chemical induction ( J:115838 )

• when treated with azoxymethane to induce colonic tumors, homozygotes develop greater number of tumors and tumor size is larger, indicating a more rapid progression in the tumor development; tumors are classified as intramucosal carcinomas

• however, homozygotes do not develop tumors spontaneously