Phenotypes Associated with This Genotype

Genotype
MGI:3053869

• Allelic Composition: Tnxb^tm1Kmat/Tnxb^tm1Kmat
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:92581 )

• homozygous mutants die from pulmonary metastases after injection of melanoma cells earlier compared to wild-type mice

neoplasm

abnormal tumor susceptibility ( J:92581 )

• average tumor size and number of metastases are increased after injection of melanoma cells compared to wild-type mice

integument

abnormal cutaneous collagen fibril morphology ( J:92472 )

• the number of large collagen fibrils is increased and the number of small diameter collagen fibrils does not increase with age resulting in an increase in the average size of collagen fibrils in the skin of mutants