Phenotypes Associated with This Genotype

Genotype
MGI:3054097

• Allelic Composition: Cdk4^tm1Bbd/Cdk4^tm1Bbd; Cdk6^tm1Bbd/Cdk6^tm1Bbd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:92529 )

• 25% of homozygotes are dead by E14.5

• 50% dead by E18.5

neonatal lethality, complete penetrance ( J:92529 )

• of the few homozygotes to be born alive, all were dead within a few hours of birth

embryo

decreased embryo size ( J:92529 )

• embryos well formed but small

growth/size/body

decreased embryo size ( J:92529 )

• embryos well formed but small

hematopoietic system

extramedullary hematopoiesis ( J:92529 )

• decreased numbers of erythroid precursors in the liver and few in proliferative stage

• lymphoid and myeloid lineage reductions are disproportionate

• proliferative potential of all stem cells is severely reduced

abnormal erythrocyte morphology ( J:92529 )

• RBCs are megaloblastic in appearance

decreased erythrocyte cell number ( J:92529 )

• decreased peripheral RBC counts

decreased hematopoietic stem cell number ( J:92529 )

• hematopoietic stem cell numbers reduced in proportion to reduced cellularity

liver/biliary system

liver hypoplasia ( J:92529 )

• small livers with significantly reduced cellularity by E15.5