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Phenotypes Associated with This Genotype
Genotype
MGI:3054741
Allelic
Composition
Ptpn13tm1Wjh/Ptpn13tm1Wjh
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn13tm1Wjh mutation (0 available); any Ptpn13 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• males in early generations developed a mild obese phenotype
• weight difference was first noticeable at 4 months of age
• males were significantly heavier at 15 months of age
• phenotype was mostly due to white adipose tissue
• phenotype disappeared by the F9 generation

nervous system
• motor nerve recovery from a sciatic nerve crush lesion was slowed, taking up to 5 weeks as opposed to 3 weeks in controls
• sensory nerve recovery was normal however
• diminished axonal branching observed during the course of recovery from sciatic nerve crush lesion

hematopoietic system
• mice exhibit increased differentiation into T-helper 2 cells compared to in wild-type mice
• however, differentiation into other T-helper cells is normal

immune system
• mice exhibit increased differentiation into T-helper 2 cells compared to in wild-type mice
• however, differentiation into other T-helper cells is normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory