Phenotypes Associated with This Genotype

Genotype
MGI:3054742

• Allelic Composition: Cited2^tm1Bha/Cited2^tm1Bha
• Genetic Background: B6.129P2-Cited2^tm1Bha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aortic arch morphology ( J:92872 )

interrupted aortic arch ( J:92872 )

• interruption of the 4th aortic arch is seen in 2 out of 11 mutants

right aortic arch ( J:92872 )

• right-sided aortic arch is seen in 4 out of 11 mutants

abnormal inferior vena cava morphology ( J:92872 )

• bilateral inferior vena cava is seen in 7 out of 11 mutants

persistent truncus arteriosus ( J:92872 )

• a common arterial trunk is seen in 2 out of 11 mutants

abnormal direction of heart looping ( J:92872 )

• ventral (1/11) and sinistral (5/11) cardiac looping are seen

double outlet right ventricle ( J:92872 )

• double outlet right ventricle is seen in 10 out of 11 mutants

common atrioventricular valve ( J:92872 )

• a common atrioventricular valve is seen in 5 out of 11 mutants

right atrial isomerism ( J:92872 )

• right atrial isomerism is seen in 7 out of 11 mutants

dextrocardia ( J:92872 )

• the heart is found on the right side or at the midline in 7 out of 11 mutants

mesocardia ( J:92872 )

• the heart is found on the right side or at the midline in 7 out of 11 mutants

ventricular septal defect ( J:92872 )

• ventricular septal defects are seen in 10 out of 11 mutants

embryo

abnormal embryo turning ( J:92872 )

growth/size/body

right atrial isomerism ( J:92872 )

• right atrial isomerism is seen in 7 out of 11 mutants

right pulmonary isomerism ( J:92872 )

• right pulmonary isomerism is seen in 7 out of 11 mutants

situs inversus ( J:92872 )

• abdominal visceral situs inversus is seen in 1 out of 11 mutants

hematopoietic system

small spleen ( J:92872 )

• a small or rudimentary spleen is seen in 7 out of 11 mutants

immune system

small spleen ( J:92872 )

• a small or rudimentary spleen is seen in 7 out of 11 mutants

limbs/digits/tail

abnormal tail position or orientation ( J:92872 )

• the tail is on the left in 7 out of 14 mutants compared to 0 out of 23 wild-type mice

respiratory system

right pulmonary isomerism ( J:92872 )

• right pulmonary isomerism is seen in 7 out of 11 mutants