Phenotypes Associated with This Genotype

Genotype
MGI:3055159

• Allelic Composition: Tg(Myl1-Prkag3*R225Q)1Sson/0
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:92821 )

• insulin-stimulated and 5-aminoimidazole-4-carboxamide ribonucleoside-stimulated glucose transport are significantly reduced in fasted mutants

• mutants do not develop insulin resistance after 12 weeks on a high fat diet unlike wild-type mice

increased skeletal muscle glycogen level ( J:92821 )

• glyocgen content of the gastrocnemius muscle is increased 2-fold

• glycogen content 2.5 hours after exercise is significantly increased

abnormal triglyceride level ( J:92821 )

• mutants do not develop increased triglyceride levels after 12 weeks on a high fat diet unlike wild-type mice

muscle

increased skeletal muscle glycogen level ( J:92821 )

• glyocgen content of the gastrocnemius muscle is increased 2-fold

• glycogen content 2.5 hours after exercise is significantly increased