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Phenotypes Associated with This Genotype
Genotype
MGI:3055280
Allelic
Composition		 Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip3tm1Ama mutation (0 available); any Tnfaip3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:92694 )
• bone marrow derived macrophages produce more TNF, IL-6, and nitric oxide in response to LPS treatment compared to wild-type macrophages
abnormal inflammatory response ( J:92694 )
• the absolute number and percentage of myeloid cells is increased in multiple tissues

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory