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Phenotypes Associated with This Genotype
Genotype
MGI:3055364
Allelic
Composition		 Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Wap-cre)11738Mam/0
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5btm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Wap-cre)11738Mam mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland alveolus morphology ( J:92770 )
• the number of alveoli is reduced, however females are able to successfully nurse their pups
• the alveoli that are present are distended
abnormal mammary gland epithelium physiology ( J:92770 )
• increased apoptosis is seen in the mammary epithelium during late pregnancy
increased mammary gland apoptosis ( J:92770 )
• increased apoptosis is seen in the mammary epithelium during late pregnancy

integument
abnormal mammary gland alveolus morphology ( J:92770 )
• the number of alveoli is reduced, however females are able to successfully nurse their pups
• the alveoli that are present are distended
abnormal mammary gland epithelium physiology ( J:92770 )
• increased apoptosis is seen in the mammary epithelium during late pregnancy
increased mammary gland apoptosis ( J:92770 )
• increased apoptosis is seen in the mammary epithelium during late pregnancy

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory