Phenotypes for Jam3 MGI:3055423 MGI Mouse

mortality/aging

postnatal lethality ( J:92665 )

• 60% die during postnatal development

postnatal lethality, incomplete penetrance ( J:121841 )

• 75% of mice die within the first 5 weeks of life likely due to fatal multilobular pneumonia

• however, postnatal survival is increased to 60% when mice are housed in ventilated isolators

reproductive system

globozoospermia ( J:92665 )

• round spermatids lack acrosomal structures

• round spermatids lack morphological signs of polarization

abnormal seminiferous tubule morphology ( J:92665 )

• F-actin abnormally distributed

• actin bundles fail to form at Sertoli-spermatid junctions

small testis ( J:92665 )

• testis 50% smaller than wildtype

arrest of spermatogenesis ( J:92665 )

• spermatids do not differentiate to form flagella nor condensed nuclei

• epididymis lacks differentiated elongated spermatids

male infertility ( J:92665 , J:121841 )

(J:92665)

(J:121841)

immune system

increased granulocyte number ( J:121841 )

• basal levels of circulating granulocytes is increased compared to in wild-type mice 3 hours after inflammatory challenge

• however, granulocyte release from the bone marrow is normal

lung inflammation ( J:121841 )

• mice exhibit increased susceptibility to pneumonia compared to wild-type mice

increased susceptibility to bacterial infection ( J:121841 )

• unlike wild-type mice, esophagus lumen exhibit accumulation of coccobacilli likely due to a defect in esophageal contraction

digestive/alimentary system

enlarged esophagus ( J:121841 )

abnormal digestive system physiology ( J:121841 )

• unlike wild-type mice, esophagus lumen exhibit accumulation of coccobacilli likely due to a defect in esophageal contraction

respiratory system

abnormal respiratory system physiology ( J:121841 )

• bronchial contraction following stimulation with methcholine are absent