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Phenotypes Associated with This Genotype
Genotype
MGI:3055864
Allelic
Composition		 Ercc1tm2Jhjh/Ercc1tm2Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc1tm2Jhjh mutation (0 available); any Ercc1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:41161 )
• maximal age seen is 78 days on a mixed 129P2/OlaHsd/FVB background, however life spans are longer on a mixed 129P2/OlaHsd/C57BL/6 background
• embryonic lethality is not seen on a mixed 129P2/OlaHsd/FVB background unlike on a mixed 129P2/OlaHsd/C57BL/6 background

growth/size/body
decreased body size ( J:41161 )
• homozygotes are severely runted
• on a mixed 129p2/OlaHsd/C57BL/6 background males are more severely runted than females, this difference is not seen on a mixed 129P2/OlaHsd/FVB background

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory