Phenotypes Associated with This Genotype

Genotype
MGI:3056261

• Allelic Composition: Etv6^tm2.1Sho/Etv6^tm2.1Sho
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:93052 )

• about 95% of embryos died by E11

prenatal lethality, complete penetrance ( J:93052 )

• embryos surviving past E11 were superficially normal at E18.5 but still not born alive

embryo

absent vitelline blood vessels ( J:93052 )

• failure of yolk sac angiogenesis in embryos dying before E11

hematopoietic system

abnormal erythropoiesis ( J:93052 )

• mice surviving past E11 with normal fetal liver hematopoiesis

• markedly reduced bone marrow hematopoiesis

cardiovascular system

absent vitelline blood vessels ( J:93052 )

• failure of yolk sac angiogenesis in embryos dying before E11