Phenotypes Associated with This Genotype

Genotype
MGI:3056739

• Allelic Composition: Gmfb^tm1Lim/Gmfb^tm1Lim
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal eye blink conditioning behavior ( J:92932 )

• mutants have impaired ability to acquire eye blink conditioning especially for the first 3 days of training, with repeated training the difference between wild-type and mutants decreases

impaired balance ( J:92932 )

• mutants have difficulty balancing on a narrow beam and do not improve with repeated trials

• however mutants have normal activity and anxiety levels, simple position discrimination, and swimming ability

nervous system

abnormal metencephalon morphology ( J:92932 )

• neurons are absent in the dorsal accessory nucleus and dorsal part of the principal nucleus of the inferior olive