Phenotypes Associated with This Genotype

Genotype
MGI:3511169

• Allelic Composition: Traf3ip2^tm1.1Lix/Traf3ip2^tm1.1Lix; Tnfsf13b^tm1Msc/Tnfsf13b^tm1Msc
• Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:93923 )

• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes

• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes

decreased B cell number ( J:138560 )

• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen

decreased transitional stage B cell number ( J:138560 )

decreased mature B cell number ( J:138560 )

• total number of mature B cells is reduced

decreased follicular B cell number ( J:138560 )

immune system

enlarged spleen ( J:93923 )

• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes

• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes

decreased B cell number ( J:138560 )

• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen

decreased transitional stage B cell number ( J:138560 )

decreased mature B cell number ( J:138560 )

• total number of mature B cells is reduced

decreased follicular B cell number ( J:138560 )

enlarged lymph nodes ( J:93923 )

• enlargement of the lymph nodes is reduced compared to Traf3ip2 single homozygotes

increased autoantibody level ( J:138560 )

• mutants develop anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens, although to a lower level than in Traf3ip2 single homozygotes due to the low number of B cells, but higher levels than in Tnfsf13b single homozygotes

growth/size/body

enlarged spleen ( J:93923 )

• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes

• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes