Analysis Tools
behavior/neurological
head bobbing
(
J:93998
)
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• head bobbing observed following weaning
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hyperactivity
(
J:93998
)
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• appeared hyperactive after weaning
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hearing/vestibular/ear
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• at E18.5 and P1, apical stereocilia bundles of inner hair cells did not exhibit a height gradient and inner hair cell stereocilia were disorganized
• at P1, the basal inner hair cell stereocilia were disorganized
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• at P20, the inner hair cell stereocilia had more stereocilia sprouting from each cell that had elongated and fused together to form giant stereocilia
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• at E18.5 and P1, apical stereocilia bundles of outer hair cells did not exhibit a height gradient
• at P20, the apical outer hair cell bundles formed a more circular pattern
• at P1, basal outer hair cell stereocilia bundles formed a U-shape rather than a V-shape
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• at P20, utricles displayed bundles of very long and thin rigid stereocilia without the normal staircase arrangement while at 5 months, stereocilia bundles lost their rigidity, were splayed and lay against the utricular surface and showed wispy ends
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• 20-23 day old mutants displayed a large increase in the compound action potential thresholds from the round window of the cochlea at low frequencies (3-12 kHz)
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nervous system
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• at E18.5 and P1, apical stereocilia bundles of inner hair cells did not exhibit a height gradient and inner hair cell stereocilia were disorganized
• at P1, the basal inner hair cell stereocilia were disorganized
|
|
• at P20, the inner hair cell stereocilia had more stereocilia sprouting from each cell that had elongated and fused together to form giant stereocilia
|
|
• at E18.5 and P1, apical stereocilia bundles of outer hair cells did not exhibit a height gradient
• at P20, the apical outer hair cell bundles formed a more circular pattern
• at P1, basal outer hair cell stereocilia bundles formed a U-shape rather than a V-shape
|
|
• at P20, utricles displayed bundles of very long and thin rigid stereocilia without the normal staircase arrangement while at 5 months, stereocilia bundles lost their rigidity, were splayed and lay against the utricular surface and showed wispy ends
|
|
• 20-23 day old mutants displayed a large increase in the compound action potential thresholds from the round window of the cochlea at low frequencies (3-12 kHz)
|
