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Phenotypes Associated with This Genotype
Genotype
MGI:3513475
Allelic
Composition		 Tdrd12repro23/Tdrd12repro23
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tdrd12repro23 mutation (1 available); any Tdrd12 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:166101 )
N
• no decrease in the number of Leydig cells is detected
abnormal male germ cell morphology ( J:166101 )
• seminiferous tubules contain many germ cells with condensed nuclei probably representing degenerating spermatocytes
azoospermia ( J:92463 , J:166101 )
• no epididymal sperm recovered (J:92463)
• absence of spermatozoa in the seminiferous tubules (J:166101)
abnormal spermatid morphology ( J:166101 )
• absence of spermatids in the seminiferous tubules
decreased testis weight ( J:92463 , J:166101 )
• low testis weight (J:92463)
• average testes weight is less than 1/3 that of wild-type or heterozygous controls (J:166101)
arrest of male meiosis ( J:92463 )
• arrest of spermatogenesis predominantly at pachytene spermatocyte stage
decreased epididymis weight ( J:166101 )
• slight but significant decrease in weight
male infertility ( J:92463 , J:166101 , J:202012 )
(J:92463)
(J:166101)
(J:202012)
abnormal sperm physiology ( J:202012 )
• derepression of retrotransposons in germ cells

endocrine/exocrine glands
decreased testis weight ( J:92463 , J:166101 )
• low testis weight (J:92463)
• average testes weight is less than 1/3 that of wild-type or heterozygous controls (J:166101)

cellular
abnormal male germ cell morphology ( J:166101 )
• seminiferous tubules contain many germ cells with condensed nuclei probably representing degenerating spermatocytes
azoospermia ( J:92463 , J:166101 )
• no epididymal sperm recovered (J:92463)
• absence of spermatozoa in the seminiferous tubules (J:166101)
abnormal spermatid morphology ( J:166101 )
• absence of spermatids in the seminiferous tubules
arrest of male meiosis ( J:92463 )
• arrest of spermatogenesis predominantly at pachytene spermatocyte stage

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory